Yoshiki Waterhouse was born in Toronto, Canada. His design work combines his interests in typography, mathematics, science and music. As an undergraduate in architecture at Yale, he designed sets and posters for theatre, eventually winning the university's Lohmann Prize for Printing. He also sang for many of Yale's professional choruses and singing groups, and in 1994 was made Music Director of the famed Whiffenpoofs, the oldest group of its kind. Upon graduation Mr. Waterhouse moved back to Toronto to work both as a designer for Bruce Mau and as a singer for the baroque period ensemble Tafelmusik. At Mau's office, he combined his interests in music and design with the graphics and packaging designs for the film series Yo-Yo Ma: Inspired by Bach. He further honed his typographic skills at Gottshalk+Ash International before moving to New York to work for the designer Massimo Vignelli. Work with Mr. Vignelli has included: the redesign of The New Yorker magazine; the entrance screen wall at the Asia Society; a year-long identity proposal for Lincoln Center; the signage programs for the Asia Society, forthcoming JFK Terminals 8 and 9, and the Museum of Fine Arts, Houston, which won an SEGD Honor Award. In 2001, he was chosen by Print magazine as one of the top twenty graphic designers in America in their twenties.

While continuing to work in New York as a graphic designer, Mr. Waterhouse studies molecular biology at Columbia University.